Assessing the Effect of Blood Perfusion on Prostate Cancer Hyperthermia Using a Bioheat Simulation Approach
DOI:
https://doi.org/10.22399/ijcesen.4352Keywords:
Hyperthermia, Prostate cancer, Blood perfusion, Temperature Distribution, Thermal damageAbstract
The development of hyperthermia-based therapy for prostate cancer requires precise modeling of the thermal behavior of biological tissues. In order to simulate healthy tissue, this study creates a computational model of a prostate tumor that is shaped like a spherical area encircled by another concentric sphere. The investigation focuses on the effects of blood perfusion rate fluctuations on the temperature distribution and subsequent thermal damage in the surrounding tissue and tumor. The heating source is modeled as a collection of electric dipoles at the center of the tumor that are subjected to a microwave (2.45 GHz) alternating electromagnetic field. The temporal evolution of temperature and tissue necros is under varying perfusion rates is described using the Arrhenius damage model and the Pennes bioheat transfer equation. The findings contribute to the development of safer and more effective hyperthermia-based treatments for prostate cancer by offering a quantitative understanding of the effects of blood flow on heat diffusion and necrotic percentage
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