Effects of Acetyl-L-Carnitine Administration on Auditory Evoked Potentials in Rats Exposed to Chronic Ethanol

Authors

  • Hakan Er Akdeniz University, Vocational School of Health Services, Department of Medical Imaging Techniques, 07070, Antalya-Turkiye https://orcid.org/0000-0001-7739-4712
  • Deniz Kantar Akdeniz University, Faculty of Medicine, Department of Biophysics, 07070, Antalya-Turkiye
  • Alev Duygu Acun Akdeniz University, Faculty of Medicine, Department of Biophysics, 07070, Antalya-Turkiye
  • Ayşegül Gemici Akdeniz University, Faculty of Medicine, Department of Biophysics, 07070, Antalya-Turkiye
  • Narin Derin Akdeniz University, Faculty of Medicine, Department of Biophysics, 07070, Antalya-Turkiye
  • Sevim Ercan Kelek Akdeniz University, Vocational School of Health Services, Department of Medical Laboratory Techniques, 07070, Antalya-Turkiye

DOI:

https://doi.org/10.22399/ijcesen.252

Keywords:

Chronic Alcoholism, Auditory Evoked Potential, Acetyl-L-Carnitine, Rat

Abstract

These days, one of the biggest issues facing public health is chronic alcohol consumption. Prolonged alcohol intake has been associated with a number of illnesses, including pancreatitis, cerebrovascular illnesses, and liver damage. It is known that the endogenous molecule acetyl-L-carnitine (ALCAR) has neuroprotective properties. The objective of this study was to examine the impact of ALCAR on auditory evoked potentials (AEP) in a model of chronic alcoholism in rats. Four groups (n = 10) were randomly formed from 40 three-month-old albino Wistar rats: Sham (Sh), chronic ethanol (CE), ALCAR administered (ALCAR), and chronic ethanol+ALCAR (CE+ALCAR).  The rats were administered either distilled water, ethanol, ALCAR, or ethanol+ALCAR via gavage for a duration of 4 weeks.  AEP recordings were acquired from each rat upon the conclusion of the experiment period. The amplitudes of P1N1 and N1P2, in addition to the latencies of the P1, N1, and P2 peaks, were analyzed. Our findings showed that P1, N1, and P2 latencies were considerably prolonged in the CE group compared to the Sh group. Furthermore, the amplitudes of P1N1 and N1P2 exhibited an increase in the CE group relative to the Sh group, a decline in the CE+ALCAR group in comparison to the CE group, and a subsequent return to normal levels. Finally, our results demonstrated that, at the dose and duration used here, ALCAR normalized the increased neuronal activity but had no effect on the conduction velocity of the hearing signal.

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Published

2024-02-07

How to Cite

Er, H., Kantar, D., Acun, A. D., Gemici, A., Derin, N., & Ercan Kelek, S. (2024). Effects of Acetyl-L-Carnitine Administration on Auditory Evoked Potentials in Rats Exposed to Chronic Ethanol. International Journal of Computational and Experimental Science and Engineering, 10(1). https://doi.org/10.22399/ijcesen.252

Issue

Vol. 10 No. 1 (2024): IJCESEN

Section

Research Article

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