Investigation of Shielding Parameters of Fast Neutrons for Some Chemotherapy Drugs by Different Calculation Methods

Abstract

In this study, we investigated the neutron attenuation properties of twelve different
chemotherapy drugs utilizing various computational techniques. The computed fast
neutron effective removal cross-section (ΣR, cm-1
) results were compared with empirical
formulas, Monte Carlo simulation data obtained from MCNP, MRCsC, and Phy-X/PSD
computer program results. Additionally, within each calculation method, the half-value
layer (HVL) and the mean free path (λ) values were determined. Our calculations
revealed that, when compared to water and paraffin, Gemcitabine, Etoposide, Vincristine,
and Doxorubicin exhibited the highest ΣR values, while Oxaliplatin exhibited the lowest
ΣR value. Understanding and determining the radiation properties of drugs, especially in
treatment methods involving radiation, will provide an advantage for both patients and
clinical personnel.