Effect of Physıcal Therapy on Bıochemıcal Parameters in Female Patıents wıth Gonartrosıs
DOI:
https://doi.org/10.22399/ijcesen.1451Keywords:
Gonarthrosis , physical therapy , lipid peroxidation, antioxidant, triglycerideAbstract
This study investigated the effects of hotpack, transcutaneous electrical nerve stimulation, ultrasound and home exercise program applied around the knee on blood lipid peroxidation system and antioxidant system in female patients with gonarthrosis.The group (n=32) underwent a hotpack, transcutaneous electrical nerve stimulation, ultrasound and home exercise. Sociodemographic and clinical characteristics of patients were recorded. Kan lipit peroksidasyon seviyeleri and total oxidant levels are measured with blood samples before and after treatment (4th week). A significant, positive, moderate level relationship (p=0.00) was found between reduced glutathione level and oxidative stress index level before physical therapy in female patients with gonarthrosis, and a statistically significant, negative, moderate level relationship was found between reduced glutathione level and paraoxonase activity level before physical therapy (p=0.03).No statistically significant difference was found between the reduced glutathione level and lipid peroxidation, high density lipoprotein, triglyceride and low-density lipoprotein levels of the participants (p>0.05). This will also contribute to the scientific literature by providing a new dimension that various physical therapy meth
References
[1] Güven A, Nur G.Deveci H.A. Liver Injury Due to Chemıcal Poisoning and Antioxidant Defense System, Oxsidative Stres and Defanse System. Editör: Aysel Güven. Paris: Livre de Lyon; 2021
[2] Güven A, Güven A, Gülmez M. (2003). The Effect of Kefir on the Activities of GSH-Px, GST, CAT, GSH and LPO Levels in Carbon tetrachloride-Induced Mice Tissues. J. Vet. Med. B 50; 50(1):412-416.
[3] Özcan O, Erdal H, Çakırca G, Yönden Z. (2015). Oxidative stress and its effects on intracellular lipid, protein and DNA structures. Journal of Clinical and Experimental Investigations, 6(3), 331-336.
[4] Jakubczyk K, Dec K, Kałduńska J, Kawczuga D, Kochman J, Janda K. (2020). Reactive oxygen species - sources, functions, oxidative damage. Pol Merkur Lekarski. 22;48(284):124-127. PMID: 32352946.
[5] Güven A, Nur G, Deveci HA. (2019). The Effects of Green tea (Camellia sinensis L.) and Parsley (Petroselinum crispum) Diets on the Activities of GSH-Px, GST, CAT, GSH and LPO Levels in Mice Tissues. Parlar Scientiific publications, 28(9):6521-6527. https://www.researchgate.net/publication/337166886
[6] Fitowska A, Ostałowska A, Dobrakowski M, et al. (2012). Protein metabolism in the synovial membrane in the hip osteoarthritis.Pol Orthop Traumatol 11:77:21-6.
[7] Tudorachi, N. B., Totu, E. E., Fifere, A., Ardeleanu, V., Mocanu, V., Mircea, C., ... & Cărăuşu, E. M. (2021). The implication of reactive oxygen species and antioxidants in knee osteoarthritis. Antioxidants, 10(6), 985.
[8] Hapeta B, Koczy B, Fitowska A, et al. (2012). Metabolism and protein transformations in synovial membrane of a knee joint in the course of rheumatoid arthritis and degenerative arthritis. Pol Orthop Traumatol 77:1-6. 17.
[9] Islam, M. T., Sarkar, C., Hossain, R., Bhuia, M. S., Mardare, I., Kulbayeva, M., ... & Cho, W. C. (2023). Therapeutic strategies for rheumatic diseases and disorders: targeting redox imbalance and oxidative stress. Biomedicine & Pharmacotherapy, 164, 114900.
[10] Amirkhizi, F., Hamedi-Shahraki, S., & Rahimlou, M. (2023). Dietary total antioxidant capacity is associated with lower disease severity and inflammatory and oxidative stress biomarkers in patients with knee osteoarthritis. Journal of Health, Population and Nutrition, 42(1), 104.
[11] Kural A, Kural C, Çetinus ME, Erçin E, Seval H, Koldaş M. (2014). Oxidative Stress in Osteoarthritis Cartilage; Comparative Study. Eur J Basic Med Sci. 4(3), 83-88.
[12] Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR. (1995). Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration. J Clin Invest 96:2859–69.
[13] Atay T, Aslan A, Baydar M.L, Ceylan B, Baykal B, Kırdemir V. (2008). Comparison of viscosupplementation applications after arthroscopic debridement in patients with gonarthrosis. Acta Orthop et Traumatol Turc 42(4):228-33.
a. ? Aksoy, N. H., Caliskan, Z., & Ozdemirler, G. (2022). Plasma lipids, lipid peroxides and antioxidant system in osteoarthritic patients underwent spa therapy. Medical Science and Discovery, 9(9), 495-500.
[14] Aslan A, Aydoğan NH, İlhan M, Özerdemoğlu RA, Altuntaş İ, & Yorgancıgil H. (2012). Effect of different intra-articular drug applications on antioxidant system and lipid peroxidation in gonarthrosis. Gaziantep Medical Journal, 18(1), 1-6.
[15] Belcher C, Yaqub FNM, Fawthrop F et al. (1997). Synovial fluid chondroidin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in arthritic and normal knees. Ann Rheum Dis. 56: 299–307.
[16] Nnoaham KE, Kumbang J. (2008). Transcutaneous electrical nerve stimulation (TENS) for chronic pain. Cochrane Database Syst Rev. 16(3), CD003222 doi: 10.1002/14651858.CD003222.pub2.
[17] Sarıfakıoğlu B, Yıldırım Güzelant A, Özduran E. (2014). Comparison of Short-Wave Diathermy and Ultrasound Treatment Efficacy in the Treatment of Gonarthrosis. Turk J Osteoporos. 20:16-20.
[18] Candeniz, Ş., Çitaker, S., Maraş, G., Yavuzer, H. E., Yildirim, H., & Günendi, Z. (2023). Comparison of the effectiveness of instrument-assisted soft tissue mobilization and extracorporeal shock wave therapy in myofascial pain syndrome. Turkish Journal of Medical Sciences, 53(6), 1825-1839.
[19] Wu, T., Li, S., Ren, J., Wang, D., & Ai, Y. (2022). Efficacy of extracorporeal shock waves in the treatment of myofascial pain syndrome: a systematic review and meta-analysis of controlled clinical studies. Annals of translational medicine, 10(4), 165.
[20] Toopchizadeh, V., Izadseresht, B., Eftekharsadat, B., Salehi-Pourmehr, H., & Dolati, S. (2024). Effectiveness of transcutaneous electrical nerve stimulation (TENS) modality for treating myofascial pain syndrome: A systematic review and meta-analysis. Journal of Research in Clinical Medicine, 12(1), 14-14
[21] Filiz MB, Firat SC. (2018). Effects of Physical Therapy on Pain, Functional Status, Sagittal Spinal Alignment, and Spinal Mobility in Chronic Non-specific Low Back Pain. Eurasian J Med. 51(1):22–26. doi:10.5152/eurasianjmed.2018.18126.
[22] Placer ZA, Cushman LL, Johnson BC 1966 Anal Biochem. 16, 359-364
[23] Sedlak J, Lindsay RH. (1968). Anal Biochem. 25;192-205.
[24] Eckerson HW, Romson J, Wyte CM, La Du BN. (1983). The human serum paraoxonase polymorphism: Identification of phenotypes by their response to salts. Am. J. Hum. Genet 35, 214-227.
[25] Kösecik M, Erel O, Sevinc E, Selek S. (2005). Increased oxidative stress in children exposed to passive smoking. Int J Cardiol. 100, 61-64.
[26] Friedewald WT, Levy RI, Fredrickson DS (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the prepartive ultracentrifuge, Clin Chem, 18: 499- 505.
[27] Alkadi H. (2020). A review on free radicals and antioxidants. Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious Disorders), 20(1), 16-26.
[28] Sutipornpalangkul W, Morales PN, Harnroongroj T. (2009). Free radicals in primary knee osteoarthritis.J Med Assoc Thai 92:268-71.
[29] Yılmaz E, Yılmaz S, Karakurt L, Serin E. (2004). Nitric oxide and malondialdehyde levels in osteoarthritis. Arthroplasty Arthroscopic Surgery Journal. 15(1):7-11.
[30] Sutipornpalangkul W, Morales PN, Harnroongroj T. (2009). Free radicals in primary knee osteoarthritis.J Med Assoc Thai 92:268-71.
[31] Aksoy, N. H., Caliskan, Z., & Ozdemirler, G. (2022). Plasma lipids, lipid peroxides and antioxidant system in osteoarthritic patients underwent spa therapy. Medical Science and Discovery, 9(9), 495-500.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 International Journal of Computational and Experimental Science and Engineering
This work is licensed under a Creative Commons Attribution 4.0 International License.
