Comparative Biological Activities of Free and Nanofiber-Released Padina pavonica Extracts from Electrospun PAN/PLA Nanofibers
DOI:
https://doi.org/10.22399/ijcesen.5406Keywords:
Padina pavonica, electrospun nanofiber, controlled release, antibacterial activity, anticancer activityAbstract
Padina pavonica is a brown marine macroalga rich in bioactive compounds with antibacterial and anticancer properties. However, the instability and rapid diffusion of these compounds may reduce their biological effectiveness. In this study, P. pavonica extracts were incorporated into electrospun polyacrylonitrile (PAN) and polylactic acid (PLA) nanofibers to achieve sustained release and improve biological performance. The released extracts and free extracts were evaluated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis. Cytotoxic activity was assessed using MCF-7, HT-29, and L929 cell lines. The released extracts exhibited prolonged antibacterial activity and selective cytotoxicity against cancer cells while showing low toxicity toward healthy fibroblasts. These findings demonstrate that electrospun PAN and PLA nanofibers are promising delivery platforms for P. pavonica extracts and may contribute to future biomedical and pharmaceutical applications.
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