The Role of Telomerase Activity in Virus- Induced Infections
DOI:
https://doi.org/10.22399/ijcesen.544Keywords:
Virus, Infection, Telomere, TelomeraseAbstract
Kromozomların doğrusal uçlarında yer alan telomer adı verilen yapılar, kromozom bütünlüğünün korunmasında önemli rol oynar. Kısa telomerler, DNA hasarı tarafından üretilenlere benzer sinyaller üreterek hem yaşlanmaya hem de programlanmış hücre ölümüne yol açar. Telomeraz enzimi, telomer zincirlerinin uzun kalması için kısalmış telomerleri onarır. Telomerler üzerindeki telomeraz enziminin aktivasyonunu anlamaya yönelik çalışmalar, bu enzimin canlı hücreleri üzerinde hücresel gençleşmeye olumlu etki yapacağını, canlı hücrelerinin yaşam süresini uzatacağını, böylece yaşa bağlı hastalıkları oluşmadan önleyeceğini ve ayrıca yaşlılığa bağlı olarak gelişebilecek birçok kanser türünün ilk etapta ortaya çıkmasını imkansız hale getireceğini göstermiştir. Bu, hücrenin bölünme yeteneğini arttırır. Telomerazın hücresel transformasyon ve karsinogenezdeki rolünü belirlemek için telomeraz aktivitesi ile hayvan ve insan tümöral virüsleri arasındaki ilişkiyi araştıran çalışmalar yapılmaktadır. İnsan ve hayvan somatik hücrelerinde telomeraz aktivitesi çok az olmasına veya hiç olmamasına rağmen, telomeraz aktivitesinin onkojenik virüslerle enfekte olmuş hücrelerde devam ettiği ve hücresel yaşlanmayı önleyebileceği öne sürülmüştür. İlginç bir şekilde, insan ve hayvan onkojenik virüsleri, geliştirdikleri mekanizmalar aracılığıyla telomeraz enzimini yeniden aktive edebilir. Bu derleme, viral enfeksiyon ile telomeraz aktivitesi arasındaki ilişkiyi araştıran çalışmalardan derlenmiştir.
References
Riethman, H. C., Xiang, Z., Paul, S., Morse, E., Hu, X. L., Flint, J., Chi, H. C., Grady, D. L., & Moyzis, R. K. (2001). Integration of telomere sequences with the draft human genome sequence. Nature, 409, 948-951. https://doi.org/10.1038/35057180 DOI: https://doi.org/10.1038/35057180
Blasco, M. A. (2005). Telomeres and human disease: Aging, cancer and beyond. Nature Reviews Genetics, 6(8), 611-622. doi: 10.1038/nrg1656. DOI: https://doi.org/10.1038/nrg1656
Neumann, A. A., & Reddel, R. R. (2002). Telomere maintenance and cancer? Look, no telomerase. Nature Reviews Cancer, 2, 879-884. https://doi.org/10.1038/nrc929 DOI: https://doi.org/10.1038/nrc929
De Lange, T. (2005). Shelterin: The protein complex that shapes and safeguards human telomeres. Genes & Development, 19(18);2100-2110. DOI: 10.1101/gad.1346005 DOI: https://doi.org/10.1101/gad.1346005
Smogorzewska, A., & De Lange, T. (2004). Regulation of telomerase by telomeric proteins. Annual Review of Biochemistry, 73, 177-208. doi: 10.1146/annurev.biochem.73.071403.160049. DOI: https://doi.org/10.1146/annurev.biochem.73.071403.160049
Smith, J. S., & Johnson, F. B. (2010). Isolation of G-Quadruplex DNA using NMMSepharose affinity chromatography. Methods in Molecular Biology, 608, 207-221. doi: 10.1007/978-1-59745-363-9_13. DOI: https://doi.org/10.1007/978-1-59745-363-9_13
Ramunas, J. E., Yakubov, J. J., Brady, S. Y., Corbel, C., Holbrook, M., Brandt, J., Stein, J. G., Santiago, J. P., & Cooke, H. M. B. (2015). Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells. The FASEB Journal, 29(5), 1930-1939. doi: 10.1096/fj.14-259531. DOI: https://doi.org/10.1096/fj.14-259531
Eskiocak, U. (2007). Investigation of telomerase activity in diagnosis of endometrial and cervical cancer (Yüksek Lisans tezi, ODTÜ Fen Bilimleri Enstitüsü, Ankara).
Jiang, J., Miracco, E. J., Hong, K., Eckert, B., Chan, H., Cash, D. D., Min, B., Zhou, Z. H., Collins, K., & Feigon, J. (2013). The architecture of Tetrahymena telomerase holoenzyme. Nature, 496, 187-192. https://doi.org/10.1038/nature12062 DOI: https://doi.org/10.1038/nature12062
Griffith, D. J., Corneau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Mossus, H., & De Lange, T. (1999). Mammalian telomeres an in a large duplex loop. Cell, 97, 503-514. DOI: https://doi.org/10.1016/S0092-8674(00)80760-6
Hartwig, F. P., Goedert, L., Wagner, M. S., & Schultze, E. (2014). Tumor cell development: A role for viruses and telomerase activity? Advances in Tumor Virology, 4, 7-16. DOI: https://doi.org/10.4137/ATV.S12440
Bellon, M., & Nicot, C. (2008). Regulation of telomerase and telomeres: Human tumor viruses take control. Journal of the National Cancer Institute, 100, 98-108. DOI: https://doi.org/10.1093/jnci/djm269
Miura, N., Horikawa, I., Nishimoto, A., Ohmura, H., Ito, H., Hirohashi, S., Shay, J. W., & Oshimura, M. (1997). Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genetics and Cytogenetics, 93, 56-62. DOI: https://doi.org/10.1016/S0165-4608(96)00329-9
Kerekhanjanarong, V., Sitawarin, S., Sakdikul, S., Saengpanich, S., Chindavijak, S., Supiyaphun, P., Voravud, N., & Mutirangura, A. (2000). Telomerase assay and nested polymerase chain reaction from nasopharyngeal swabs for early noninvasive detection of nasopharyngeal carcinoma. Otolaryngology-Head and Neck Surgery, 123, 624-629. DOI: https://doi.org/10.1067/mhn.2000.109368
Flore, O., Rafii, S., Ely, S., O’Leary, J. J., Hyjek, E. M., & Cesarman, E. (1998). Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature, 394, 588-592. DOI: https://doi.org/10.1038/29093
Shkreli, M., Dambrine, G., Soubieux, D., Kut, N., & Rasschaert, D. (2007). Involvement of the oncoprotein c-Myc in viral telomerase RNA gene regulation during Marek's disease virus-induced lymphomagenesis. Journal of Virology, 81(9), 4848-4857. doi: 10.1128/JVI.02530-06. DOI: https://doi.org/10.1128/JVI.02530-06
Fragnet, L., Blasco, M. A., Klapper, W., & Rasschaert, D. (2003). The RNA subunit of telomerase is encoded by Marek's disease virus. Journal of Virology, 77, 5985-5996. doi: 10.1128/jvi.77.10.5985-5996.2003. DOI: https://doi.org/10.1128/JVI.77.10.5985-5996.2003
Szczotka, M., & Kuzmak, J. (2013). Telomerase activity and telomere length in cattle infected with bovine leukemia virus (BLV). Journal of Comparative Pathology, 148, 70. DOI:10.1016/J.JCPA.2012.11.096 DOI: https://doi.org/10.1016/j.jcpa.2012.11.096
Hemmatzadeh, F., Keyvanfar, H., Hasan, N. H., Niap, F., Bani Hassan, E., Hematzade, A., Ebrahimie, E., McWhorter, A., & Ignjatovic, J.
(2015). Interaction between Bovine leukemia virus (BLV) infection and age on telomerase misregulation. Veterinary Research Communications, 39, 97-103. DOI: 10.1007/s11259-015-9629-2 DOI: https://doi.org/10.1007/s11259-015-9629-2
Zhang, X., Dong, N., Zhang, H., You, J., Wang, H., & Ye, L. (2005). Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells. Journal of Laboratory and Clinical Medicine, 145, 98-104. DOI: https://doi.org/10.1016/j.lab.2004.11.018
Zheng, H., Li, L. L., Hu, D. S., Deng, X. Y., & Cao, Y. (2007). Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cellular & Molecular Immunology, 4, 185-196. https://doi.org/10.1002/anie.202302689 DOI: https://doi.org/10.1002/anie.202302689
Rac, J., Haas, F., Schumacher, A., Middeldorp, J. M., Delecluse, H. J., Speck, R. F., Bernasconi, M., & Nadal, D. (2015). Telomerase activity impacts on Epstein-Barr virus infection of AGS cells. PLOS ONE, 10(4), 1-24. https://doi.org/10.1371/journal.pone.0123645 DOI: https://doi.org/10.1371/journal.pone.0123645
Mei, Y. P., Zhu, X. F., Zhou, J. M., Huang, H., Deng, R., & Zeng, Y. X. (2006). siRNA targeting LMP1-induced apoptosis in EBV-positive lymphoma cells is associated with inhibition of telomerase activity and expression. Cancer Letters, 232, 189-198. DOI: https://doi.org/10.1016/j.canlet.2005.02.010
Chen, F., Liu, C., Lindvall, C., Xu, D., & Ernberg, I. (2005). Epstein-Barr virusu, latent membran 2A (LMP2A) telomeraz epitel hücre hatlarında transkriptazı (hTERT) ters aşağı regüle. International Journal of Cancer, 113, 284-289. DOI: https://doi.org/10.1002/ijc.20594
Dolcetti, R., Giunco, S., Col, D. J., Celeghin, A., Mastorci, K., & De Rossi, A. (2014). Epstein-Barr virus and telomerase: From cell immortalization to therapy. Infectious Agents and Cancer, 9, 8. DOI: https://doi.org/10.1186/1750-9378-9-8
Feng, Y., Xian, R. R., Li, Y., Polony, T. S., & Beemon, K. L. (2007). Telomerase reverse transcriptase expression elevated by avian leukosis virus integration in B cell lymphomas. Proceedings of the National Academy of Sciences, 104, 18952-18957. DOI: https://doi.org/10.1073/pnas.0709173104
Bryan, T. M., & Reddel, R. R. (1997). Telomere dynamics and telomerase activity in in vivo immortalised human cells. European Journal of Cancer, 33(5), 767-773. DOI: https://doi.org/10.1016/S0959-8049(97)00065-8
Hoffman, T. W., van Moorsel, C. H. M., Borie, R., & Crestani, B. (2018). Pulmonary phenotypes associated with genetic variation in telomere-related genes. Current Opinion in Pulmonary Medicine, 24(3), 269-280. https://doi.org/10.1097/MCP.0000000000000475 DOI: https://doi.org/10.1097/MCP.0000000000000475
Ekert, J. E., Murray, L. A., Das, A. M., Sheng, H., Giles-Komar, J., & Rycyzyn, M. A. (2011). Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes. Fibrogenesis & Tissue Repair, 4(1), 23. doi: 10.1186/1755-1536-4-23. DOI: https://doi.org/10.1186/1755-1536-4-23
Conte, E., Gili, E., Fagone, E., Fruciano, M., Lemmolo, M., & Vancheri, C. (2014). Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts. European Journal of Pharmaceutical Sciences, 58, 13-19. DOI: 10.1016/j.ejps.2014.02.014 DOI: https://doi.org/10.1016/j.ejps.2014.02.014
Armanios, M. Y., Chen, J. J., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., et al. (2007). Telomerase mutations in families with idiopathic pulmonary fibrosis. The New England Journal of Medicine, 356(13), 1317-1326. DOI: 10.1056/NEJMoa066157 DOI: https://doi.org/10.1056/NEJMoa066157
Tsakiri, K. D., Cronkhite, J. T., Kuan, P. J., Xing, C., Raghu, G., Weissler, J. C., et al. (2007). Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proceedings of the National Academy of Sciences of the United States of America, 104(18), 7552-7557. doi: 10.1073/pnas.0701009104. DOI: https://doi.org/10.1073/pnas.0701009104
Akgül, E. (2024). The Effect of Telomerase Enzyme on Cell Aging and Cancer Formation-Treatment. International Journal of Computational and Experimental Science and Engineering, 10(3);371-380. https://doi.org/10.22399/ijcesen.403 DOI: https://doi.org/10.22399/ijcesen.403
Say, A., Çakır, D., AVRAMESCU, T., USTUN, G., NEAGOE, D., KAHVECİ, M., … KOMOREK, J. (2024). Examining the Prevalence of Long-Covid Symptoms: A Cross-Sectional Study. International Journal of Computational and Experimental Science and Engineering, 10(1);72-78. https://doi.org/10.22399/ijcesen.243 DOI: https://doi.org/10.22399/ijcesen.243
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